ACECLOFENAC

Category- Analgesic

Introduction:

Aceclofenac is a nonsteroidal anti-inflammatory medication (NSAID) that is often used to treat pain and inflammatory conditions. It is a derivative of diclofenac and has been shown to be effective in the management of conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac works by inhibiting the production of prostaglandins, which are responsible for inflammation and pain. Aceclofenac was originally developed by the Swiss pharmaceutical company Ciba-Geigy (now merged with Sandoz) in the 1980s. It was introduced to the market in the early 1990s and has since become widely used in many countries for the treatment of pain and inflammation.

Aceclofenac is administered orally as well as intravenously (injection)

Uses:

How to Consume:

• Aceclofenac should be taken as per prescribed by the doctor. The dosage form and quantity of the drug might be different for every pain and inflammation.

• Aceclofenac should be taken after food.

• The drug should be taken directly with a drink of water and avoid chewing or crushing of it in mouth.

• It may be consumed an hour following a meal.

• Store the medication in an air tight container in cool dry place. Protect form light and moisture.

Duration between two dose:

Aceclofenac is normally taken twice a day or according to prescribed by the doctor. The recommended dose is 100mg twice a day for a moderate pain relief or the dosage prescribed by the doctor according to the severity and type of pain.

It can be taken orally for 2-4 day

Side effects:

Some common side effects can be seen after taking Aceclofenac :-

• Indigestion

• Stomach irritation

• Diarrhoea

• Nausea

• Heart burn

• Abdominal pain

• Vomiting

Drug Mechanism:

Pharmacodynamics:

Aceclofenac works by inhibiting the synthesis of prostaglandins, which are substances in the body that play a role in pain, inflammation, and fever. It accomplishes this by inhibiting the action of cyclooxygenase (COX), an enzyme involved for the generation of prostaglandins.

Pharmacokinetics:

Aceclofenac can be administered orally and is available in tablet and capsule forms. It is also available as a topical gel for local application.

Aceclofenac has high bioavailability, which means that it is readily absorbed by the body after oral administration. The bioavailability of aceclofenac is approximately 100%. Aceclofenac is distributed to various tissues in the body, including the synovial fluid and synovial membrane.Aceclofenac undergoes extensive metabolism in the liver. It is metabolized to its major metabolite, 4’-hydroxyaceclofenac.The metabolism of aceclofenac is primarily mediated by cytochrome P450 enzymes, specifically CYP2C9 and CYP3A4. Aceclofenac is excreted from the body through the kidneys, primarily in the form of metabolites.

Safety Measures:

When to See doctor:

• Redness

• Swelling

• Inflammation

• Severe pain

• Stomach irritation

• Diarrhoea

• Skin rash

• Irritation/ Swelling ( especially on skin, face, throat)

• Severe dizziness

• Heartburn

If conditions from this occur you should visit the doctor or it can be dangerous for your health if not cured as soon as possible.

Allergic reactions:

This drug can cause severe allergic reactions

Symptoms include:

Aceclofenac cream may induce erythema, itching and burning in less than 3% of patients.

Aceclofenac can cause photosensitivity.

Available Dosage Form:

Form:

1) Oral Tablet (Capsule)

Strengths: 100mg, 200mg

2) Intravenous (Injection)

Strengths: 150mg

3) Gel and Creams

Strengths: 1.5%

Child Dosage

Age 14yrs below

The drug is not recommended for children below age 14yrs or as per prescribed by the doctor

Adult Dosage

Ages 14yrs and older

The standard dose is 100mg once or twice a day for 2-3days

Important Note:

• After taking aceclofenac medicine if allergic conditions are observed immediately visit the doctor and avoid further administration of it.

• Overdose of medicine should be avoided.

• The drug is not recommended in pregnant or breastfeeding women.

• Renal(kidney) and hepatic(liver) function and blood counts should be monitored during long term treatment.

• Aceclofenac should not be used in patients with a history of hypersensitivity to NSAIDs or aspirin.

• Aceclofenac is not recommended if you have been diagnosed with asthama or any bleeding disease.

• Tell the doctor if you have any medical history before.

• Follow the complete treatment prescribed by the physician, do not skip a dose in the treatment.

Various brands :